Bacterial Pathogenesis Research Group (BPRG)
The Bacterial Pathogenesis Research Group (BPRG) is a research and educational group in the Emerging Infectious Disease theme of the Institute of Infection, Immunity and Inflammation. The BPRG is comprised of scientists whose teams work to understand molecular mechanisms of bacterial diseases and develop vaccines or therapeutic targets for disease intervention. The major areas of research focus include pathogen-host interactions, virulence gene regulation, vaccine development, zoonotic diseases, bacterial communication, DNA replication and biofilm formation in chronic infections.
The BPRG provides an excellent training environment for graduate, post-doctoral and undergraduate research. We have well funded laboratories with state of the art equipment. There is a level 3 containment laboratory and a BPRG core lab that provides access to robotic equipment, plate readers, FPLC and other equipment. Additional core facilities are available through the The Calvin, Phoebe and Joan Snyder Institute of Infection, Immunity and Inflammation as well as the Faculty of Medicine. The group consists of 10 full and 6 associate members from the Faculties of Medicine, Veterinary Medicine and Science. There are currently 24 graduate students and 13 post-doctoral fellows.
BPRG Group Chair
Dr. Alexei Savchenko
Associate Professor, Department of Microbiology, Immunology and Infectious Diseases
Adjunct Associate Professor, Department of Biochemistry and Molecular Biology
- Alexei Savchenko
Structure-function studies of microbial proteins involved in pathogenesis and conferring antibiotic resistance to provide the molecular framework for development of urgently needed novel antimicrobial therapies.
- George Chaconas
Telomere resolution, DNA replication, antigenic variation and mechanisms of pathogenesis in Borreliaburgdorferi, the Lyme disease spirochete.
- Jeroen De Buck
Pathogenesis and host adaptation of Mycobacterium avium subsp. paratuberculosis.
- Rebekah DeVinney
Cellular Microbiology: E. coli O157:H7 and Vibrio parahaemolyticus interactions with intestinal. epithelial cells.
- Shawn Lewenza
Microbial pathogenesis of Pseudomonas aeruginosainfections. Understanding the process of biofilm formation and inhibition. Virulence gene regulation and environmental sensing.
- Marie-France Roy
Host response to Salmonella Typhimurium in the mouse model of typhoid fever.
- Anthony Schryvers
Molecular, biochemical and structural approaches to delineate the mechanism of iron acquisition in gram negative bacteria. Development of vaccines and therapeutic agents.