Mouse Phenomics Resource Laboratory
The mission of the Mouse Phenomics Resource Laboratory is to assist researchers within the institute and beyond as well as industry in promoting high quality, world-class research by providing support for their own driven in vivo models of interest and by generating additional novel data through the development of new in vivo screens and murine models in the field of acute and chronic inflammation and related chronic diseases.
- Initiation of new teams within the institute based on in vivo research and experimental as well as analytical support.
- Development of new in vivo screening techniques (acute and chronic disease models, non-invasive imaging techniques).
- Experimental design and data analysis for manuscript submissions and grant applications.
- Development of new mouse KO strains in collaboration with the CCCMG.
- Experimental and analytical support regarding mouse work to labs who lack in vivo experience.
- Completion and further development of ongoing experiments based on resource lab’s in vivo experience.
- Support for junior faculty with no in vivo resources.
Key Areas of Research
- Intravital and non invasive whole animal imaging
- Drug dissemination/location screens
- Acute and chronic infectious screens
- Acute and chronic inflammatory screens
- Murine models of human chronic diseases
- Metabolic screens
- Ryes J.L. et al., FASEB J 2019 Jan22 (macrophage assoc. colitis including whole body imaging)
- Zeng Z. et al., Nat Immunol. 2018 Oct;19(10) (Ab assoc. protection from bact. infection including whole body imaging)
- Andonegui G. et al., JCI Insight 2018 May 3;3(9) (sepsis assoc. brain damage including whole body imaging)
- Kim J.H. et al., Nat Immunol. 2018 Feb;19(2) (lung inflammation and arthritis model)
- Ramachandran R. et al., Mol Pharmacol. 2017 Apr;91(4) (intravital drug screen)
- Leung G. et al., Mol. Med. 2015 Dec 9. (GI inflammation including whole body imaging)
- Lopes F. et al., Arthritis Rheumatol. 2015 Aug 28. (arthritis model)
- Dal-Secco D. et al., J Exp Med. 2015 Apr 6;212(4). (liver inflammation)
- Halverson T.W. et al., PLoS Pathog. 2015 Jan 15;11(1). (bacterial skin infection)
- Prescott D. et al., Inflamm Bowel Dis. 2013 Mar;19(3). (GI inflammation)
- Yipp B.G. D. et al., Nat Med. 2012 Sep;18(9). (bacterial skin infection)
Dr. Björn Petri
Scientific Director: Mouse Phenomics Resource Laboratory, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases Research Associate Professor Dept. Microbiology, Immunology & Infectious Diseases Cumming School of Medicine, University of Calgary
HSC 2868 (lab): 403.210.6538
HSC 2825 (office): 403.220.4562
Björn Petri, PhD, MSc
Scientific Director, Research Associate Prof
Dr. Bjӧrn Petri is the Scientific Director of the Snyder Institute Mouse Phenomics Resource Laboratory since January 2011. Dr. Petri obtained his PhD (Dr. rer. nat.) in Immunology/Cell Biology and Genetics from the Westfalian Wilhelms-University and the Max-Planck-Institute for Molecular Biomedicine in Münster, Germany. Before he started his studies in the field of Immunology Dr. Petri obtained his MSc (Diploma) in Zoology and Physiology at the Max-Planck-Institute for Heart and Lung Research in Bad Nauheim and the Philipps-University in Marburg, Germany. He can look back at over 20 years of in vivo experience working with rodent models in the field of physiology and immunology.
Between 2007 and 2010 he worked as a Postdoctoral Fellow (AHFMR/AIHS) in the Snyder Institute for Chronic Diseases where he continued to strengthen his expertise in the field of Immunology and its related research models and imaging techniques.
Specialization / Applications
Acute inflammatory screens in WT and KO mice:
- Bacterial skin infection.
- Leukocyte recruitment screens in different vascular beds under physiological and infectious/inflammatory conditions.
- Permeability models under physiological and infectious/inflammatory conditions in different vascular beds.
Murine models of human chronic diseases in WT and KO mice:
- Chronic bacterial infections/sepsis.
- Serum transfer induced arthritis (K/BxN model).
- TNBS/DSS models of colitis and AOM/DSS models of colitis associated cancer.
- DTH model.
- BMT/chimeric screens.
- Access to additional models within the Snyder Institute as well as metabolic screening tools.
Intravital and non-invasive whole body imaging techniques as screening tools.
- Intravital imaging of different murine organs/vascular beds using spinning-disk confocal and multiphoton microscopy under physiological and pathological/disease conditions (in collaboration with the Live Cell Imaging Resource Laboratory).
- Development/testing of new imaging reagents/probes using non-invasive whole body imaging (BRUKER InVivoXtreme 4MP + MARS).
- Non-invasive whole body imaging screens under physiological and pathological/disease conditions.