Kris Chadee

Positions

Professor

Cumming School of Medicine, Department of Microbiology, Immunology and Infectious Diseases

Full Member

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases

Full Member

Gastrointestinal Research Group

Full Member

Inflammation Research Network

Contact information

kchadee@ucalgary.ca

Phone number

Office: +1.403.210.3975
Lab: +1.403.210.5400

Location

Office: HSC1879

Background

Educational Background

BSc Biological Sciences (Honours), University of Winnipeg,

MSc Zoology, University of Manitoba,

PhD Immunology, McGill University,

Research

Areas of Research

To understand the mechanisms whereby infectious agents, lipid mediators of inflammation and cytokines modulate innate, immune and mucosal epithelial cell functions.

Of particular interest to our group is the emerging concept that cross-talk between pathogen components and host cells or both, can predetermine the outcome of inflammatory or host defence mechanisms. Consistent with this concept, our program of research is divided into three areas as follows:

1. To define the biochemical and molecular interactions by which the colonic mucosal pathogen, Entamoeba histolytica and pathogenic bacteria modulates luminal (mucus/bacteria) and epithelial barrier functions in the gut.
2. To define how MUC2 mucin biosynthesis, secretion and function regulates innate host defences in the gut.
3. To define the cellular and molecular basis by which mucosal pathogen adhesins in contact with innate immune cells regulate NLRP3 inflammasome activation via inflammatory caspases.

Participation in university strategic initiatives

Infections, inflammation and chronic diseases

Courses

Course number	Course title	Semester
CMMB 528 LAB 01 B01	Independent Studies in CMMB	2020
CMMB 528 LAB 01 B01	Independent Studies in CMMB	2021

Awards

Research Excellence Award, Canadian Association for Gastroenterology. 2005
The Robert A. Wardle Award, Canadian Society of Zoologist by the Parasitology Section. 2005
Tier 1 Canada Research Chair, Canadian Institutes of Health Research (CIHR) . 2005
CAGF, Canadian Association of Gastroenterology. 2020
Great supervisor award, University of Calgary FGS. 2014
Great supervisor award, University of Calgary FGS. 2020

Publications

PubMed

More Information

In the Lab

MacKenzie McManus
BHSc 4-year project trainee
mackenzie.mcmanus@ucalgary.ca

Ariel Kim
PhD Student
ariel.kim1@ucalgary.ca

Priti Yadav
PhD Candidate
priti.yadav1@ucalgary.ca

Hayley Gorman
Postdoctoral Fellow
hayley.gorman1@ucalgary.ca

Banafsheh Nadalian
Postdoctoral Fellow
banafsheh.nadalian@ucalgary.ca

France Moreau
Research Associate
fmoreau@ucalgary.ca

Shanshan Wang
Lab Technician
shanshan.wang1@ucalgary.ca

Administrative Assistant

Miwa Shibuya
HRIC 1C58
mmshibuy@ucalgary.ca
403.210.8468