Preferred method of communication
Research and teaching
Instrument development is an important factor in the advancement of biomedical research. In our research on how crystalline structures interact with the immune system, particularly uric acid and alum crystals, we have found that atomic force microscopy based single cell force spectroscopy (SCFS) analysis is a robust and precise tool for measuring cell to cell and cell to particle interactions. Our extended work further suggests SCFS is a powerful tool for immunological/biomedical research in general. With this technique, we have made exciting discoveries on the mechanism of regulatory T cells: namely a probability based, Treg binding triggered DC downregulation. We propose several aims to test our hypothesis. We believe we are uniquely equipped to address this interest research topic.
2012 - New Investigator Award, Canada Society for Immunology