Wee Yong V.

Professor

Clinical Neurosciences

Associate Member

Snyder Institute for Chronic Diseases

Ph.D.

University of British Columbia

Contact information

Phone

Office: 403.220.3544

Web presence

Website

Location

Office : HMRB187

Preferred method of communication

Administrative Assistant
Tanna Giroux   
Email: tgiroux@ucalgary.ca                       
Phone: 403.220.4592


Research and teaching

Research Activities

Neuroimmunology is the study of interactions and consequences between the immune and nervous systems. Virtually all neurological disorders have inflammatory components, and these include diseases traditionally associated with overt inflammation, such as multiple sclerosis (MS), and those previously thought to be purely degenerative, including Alzheimer’s disease.  Neuroinflammation originates from the trafficking of several leukocyte subsets into the nervous system and through the production of immune molecules by neural cells themselves.  The interaction between leukocytes and neural cells further promotes CNS inflammation and injury. In recent years, reparative properties of neuroinflammation have been appreciated, so that the balance between beneficial and detrimental neuroinflammation is a crucial determinant of outcome.  My research projects have been guided by extremes of immune dysfunctions: MS with chronic inflammation, and glioblastomas where the brain tumor subjugates the immune system. I believe that lessons learned from these extremes can help each condition.  More recently and to return to my ethnic roots, I collaborate with the stroke program at Zhengzhou University in China to bring medications into intracerebral hemorrhage, a common condition in China and where secondary neuroinflammation drives injury and recovery. I am proud that my laboratory results have been translated into clinical trials as listed below. Collectively, my research is aimed at understanding, controlling and tipping the balance of neuroinflammation towards one of neuroprotection and regeneration from CNS insults.


Publications

PubMed
PubMed


Awards

  • Order of the University of Calgary, 2014
  • Fellow of the Royal Society of Canada, 2014
  • President, International Society of Neuroimmunology, 2014 – 2016
  • Researcher of the Month, Canadians for Health Research, September 2017
  • Recipient, Allyn Taylor International Prize in Medicine, 2017
  • Recipient, Killam Graduate Supervision and Mentorship Award, 2018
  • Recipient, Killam Research Award, 2019
  • Recipient, Clinician Investigator Program Telemachus Distinguished Mentorship Award, 2020