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Research and teaching
My research group investigates how the intestinal microbiota interacts with the host immune system at the level of T helper cells locally in the mucosa, systemically throughout the body, as well as centrally in the Thymus during T cell development. To study this, we make use of state-of-the art axenic and gnotobiotic in vivo models in combination with genetically modified commensal bacteria. Our research is relevant to a number of immune-mediated disorders that are modulated by the intestinal microbiota including inflammatory bowel diseases (IBD), Type 1 diabetes (T1D) as well as allergic disorders.
Dr. Markus Geuking is an Assistant Professor at the University of Calgary's Cumming School of Medicine. He is a member of the Department of Microbiology, Immunology and Infectious Diseases as well as of the Snyder Institute for Chronic Diseases. Dr. Geuking obtained his PhD in Immunology from the Federal Institute of Technology in Zurich (Switzerland) where he worked in the lab of Nobel Prize Laureate Prof. Rolf Zinkernagel. He started to work on host-microbial immune interactions using germ-free and gnotobiotic models during his postdoctoral studies at McMaster University (Hamilton, Canada). He then continued this work as a research associate at the University of Bern (Switzerland) before joining the University of Calgary in 2016.