Kris Chadee

Professor

Microbiology, Immunology and Infectious Diseases

Full Member

Snyder Institute for Chronic Diseases

PhD

McGill University, 1985

MSc

University of Manitoba, 1981

BSc (Hons)

University of Winnipeg, 1977

Contact information

Location

Office : HSC1879

Preferred method of communication

Administrative Assistant
Miwa Shibuya  
mmshibuy@ucalgary.ca
403.210.8468

Lab Manager
France Moreau
fmoreau@ucalgary.ca
403.210.5400


Research and teaching

Research Activities

Modeling how pathogens interact with and modulate host innate defenses in the gut.

A major effort underway in our laboratory is to understand the mechanisms whereby infectious agents, lipid mediators of inflammation and cytokines modulate innate, immune and mucosal epithelial cell functions. Of particular interest to our group is the emerging concept that cross-talk between pathogen components and host cells or both, can predetermine the outcome of inflammatory or host defence mechanisms. Consistent with this concept, our program of research is divided into three areas as follows:

  1.  To define the biochemical and molecular interactions by which the mucosal pathogen, E. histolytica trophozoites or its components can modulate luminal (mucus/bacteria) and epithelial barrier function in the gut.
  2.  To determine the molecular mechanisms by which PGE2 regulates pro-inflammatory responses in human colonic epithelial and immune cells.
  3.  To define the cellular and molecular basis by which E. histolytica adhesin, the Gal-lectin, can stimulate an effective cell-mediated immune response against ameba.


Publications

PubMed


Awards

- American Society for Microbiology – Distinguish editorial service (2021)

- University of Calgary GREAT supervisor award (2020)

- Canadian Association of Gastroenterology Fellow Designation (CAGF; 2020)

- University of Calgary GREAT supervisor award (2014)

- Tier 1 Canada Research Chair (2005-2019)

- Recipient of the Wardle Award, Canadian Society of Zoologist (2005)

- Canadian Society for Gastroenterology Research Excellence Award (2005)

- NSERC University Research Fellow, McGill University (1987-1996).