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Mouse Phenomics Resource Laboratory

The mission of the Snyder Institute Mouse Phenomics Resource Laboratory is to assist researchers in the institute and related faculties and to foster collaborations to promote high quality, worldclass research by providing support for their own driven in vivo models of interest and by generating additional novel data through the development of new in vivo screens and murine models in the field of acute and chronic inflammation and related chronic diseases. Thereby contributing to their scientific success and enhance the Snyder Institute and faculties research effort.

Services

  • Initiation of new teams within the institute based on in vivo research and experimental as well as analytical support.
  • Development of new in vivo screening techniques (acute and chronic disease models, non-invasive imaging techniques).
  • Experimental design and data analysis for manuscript submissions and grant applications.
  • Development of new mouse KO strains in collaboration with the CCCMG.
  • Experimental and analytical support regarding mouse work to labs who lack in vivo experience.
  • Completion and further development of ongoing experiments based on resource lab’s in vivo experience.
  • Support for junior faculty with no in vivo resources.

Contacts

Dr. Björn Petri
Research Assistant Professor
Dept. Microbiology, Immunology & Infectious Diseases
Scientific Director Mouse Phenomics Resource Laboratory
HSC 2868 (lab): 403 210-6538
HSC 2825 (office): 403 220-4562
Email: bpetri@ucalgary.ca

Key Areas of Research

  • General phenotypic screens.
  • Acute infectious/inflammatory screens in WT and KO mice.
  • Chronic infectious/inflammatory screens in WT and KO mice.
  • Murine models of human chronic diseases in WT and KO mice.
  • Pharmaceutical compound screening in WT and KO mice.
  • Intravital and non-invasive whole body imaging techniques as phenotypic screening tools.

Select Publications

  • Leung G. et al., Mol. Med, 2015 Dec 9.
  • Lopes F. et al., Arthritis Rheumatol. 2015 Aug 28.
  • Dal-Secco D. et al., J Exp Med. 2015 Apr 6;212(4).
  • Halverson T.W. et al., PLoS Pathog. 2015 Jan 15;11(1).
  • Prescott D. et al., Inflamm Bowel Dis. 2013 Mar;19(3).
  • Yipp B.G. D. et al., Nat Med. 2012 Sep;18(9).

Link to new fee structure for the Phenomics Core

Core Personnel

Björn Petri, PhD, MSc
Scientific Director, Res. Ass. Prof.

Dr. Björn Petri: Scientific Director of the Snyder Institute Mouse Phenomics Resource Laboratory since January 2011. Dr. Petri obtained his PhD (Dr. rer. nat.) in Immunology/Cell Biology and Genetics from the Westfalian Wilhelms-University and the Max-Planck-Institute for Molecular Biomedicine in Münster, Germany. Before he started his studies in the field of Immunology Dr. Petri obtained his MSc (Diploma) in Zoology and Physiology at the Max-Planck-Institute for Heart and Lung Research in Bad Nauheim and the Philipps-University in Marburg, Germany. He can look back at over 15 years of in vivo experience working with rodent models in the field of physiology and immunology.

Between 2007 and 2010 he worked as a Postdoctoral Fellow (AHFMR/AIHS) in the Snyder Institute for Chronic Diseases where he continued to strengthen his expertise in the field of Immunology and its related research models and imaging techniques.

Specialization / Applications

Acute inflammatory screens in WT and KO mice:

  • Bacterial skin infection.
  • Leukocyte recruitment screens in different vascular beds under physiological and infectious/inflammatory conditions.
  • Permeability models under physiological and infectious/inflammatory conditions in different vascular beds.

Murine models of human chronic diseases in WT and KO mice:

  • Chronic bacterial infections/sepsis.
  • Serum transfer induced arthritis (K/BxN model).
  • TNBS/DSS models of colitis and AOM/DSS models of colitis associated cancer.
  • DTH model.
  • BMT/chimeric screens.
  • Access to additional models within the Snyder Institute as well as metabolic screening tools. 

Intravital and non-invasive whole body imaging techniques as screening tools.

  • Intravital imaging of different murine organs/vascular beds using spinning-disk confocal and multiphoton microscopy under physiological and pathological/disease conditions (in collaboration with the Live Cell Imaging Resource Laboratory).
  • Development/testing of new imaging reagents/probes using non-invasive whole body imaging (BRUKER InVivoXtreme 4MP + MARS).
  • Non-invasive whole body imaging screens under physiological and pathological/disease conditions.

The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases was named in 2008 in honour of Joan Snyder and her parents, who she credits for teaching her the value of philanthropy. It is a group of more than 104 clinicians, clinician-scientists and basic scientists who are impacting and changing the lives of people suffering from chronic diseases, including sepsis, MRSA, cystic fibrosis, type-1 diabetes, inflammatory bowel disease, and chronic obstructive pulmonary disease. For more information on the Snyder Institute for Chronic Diseases, please visit us at www.snyder.ucalgary.ca or follow us on Twitter @SnyderInstitute.